Kyba Michael
Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA.
Int J Hematol. 2005 May;81(4):275-80. doi: 10.1532/ijh97.04192.
Hematopoietic stem cells first arise in the mammalian embryo in a primitive state, not capable of reconstituting hematopoiesis in irradiated adult recipients. As development proceeds, these cells eventually mature to acquire definitive, adult characteristics, including adult reconstitution ability. Mouse embryonic stem cells induced to undergo hematopoiesis in vitro readily generate primitive hematopoietic stem cells but rarely generate the definitive type. Recent work has stimulated a new appreciation of the events involved in the developmental maturation of hematopoietic stem cells. Application of this knowledge to in vitro differentiation systems will be critical to the successful development of hematopoietic therapies from embryonic stem cells.
造血干细胞最初在哺乳动物胚胎中以原始状态出现，无法在受辐射的成年受体中重建造血功能。随着发育的进行，这些细胞最终成熟以获得明确的成年特征，包括成年重建能力。在体外诱导进行造血的小鼠胚胎干细胞很容易产生原始造血干细胞，但很少产生明确类型的细胞。最近的研究激发了人们对造血干细胞发育成熟过程中所涉及事件的新认识。将这一知识应用于体外分化系统对于从胚胎干细胞成功开发造血疗法至关重要。
