[表面改性对乳糖表面能及干粉吸入剂性能的影响]
[Effect of surface modification on surface energy of lactose and performance of dry powder inhalations].
作者信息
Jiang Rong-gao, Zhang Peng-wei, Wang Li-qing, Liu Heng, Pan Wei-san, Wang Chun-long
机构信息
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Yao Xue Xue Bao. 2005 Apr;40(4):373-6.
AIM
To investigate the effects of surface modification of lactose carrier on performance of dry powder inhalations (DPIs).
METHODS
Modified lactose surface was prepared using a "particle smoothing" process to obtain smooth carrier surface and low surface energy with the presence of magnesium stearate, colloidal silica dioxide and talc. Inverse gas chromatography (IGC) was used to assess the surface energy of treated lactose, and the in vitro deposition of carrier-based IFNa-2b DPIs was evaluated with twin stage impinger.
RESULTS
The flowing property of lactose was greatly improved and the surface energy decreased by the "particle smoothing" process. Decreasing surface energy resulted in greater aspiration fraction of IFNa-2b.
CONCLUSION
IGC is a potentially useful tool for rapid formulation design and screening.
目的
研究乳糖载体表面改性对干粉吸入剂（DPI）性能的影响。
方法
采用“颗粒平滑”工艺制备改性乳糖表面，在硬脂酸镁、胶体二氧化硅和滑石粉存在的情况下获得光滑的载体表面和低表面能。采用反相气相色谱（IGC）评估处理后乳糖的表面能，并用双级撞击器评估基于载体的IFNa - 2b DPI的体外沉积。
结果
通过“颗粒平滑”工艺，乳糖的流动性得到极大改善，表面能降低。表面能降低导致IFNa - 2b的吸入分数更高。
结论
IGC是一种用于快速配方设计和筛选的潜在有用工具。
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