Graham G J, Pragnell I B
Beatson Institute for Cancer Research, Glasgow, United Kingdom.
Dev Biol. 1992 Jun;151(2):377-81. doi: 10.1016/0012-1606(92)90177-i.
The hemopoietic system represents a complex adult developmental system which allows the study of mechanisms of stem cell proliferative control and differentiation commitment. It is likely that information obtained from this model system will have implications for control processes regulating other hierarchical systems in the developing embryo as well as in the adult animal. We have recently identified and isolated a potent inhibitor of hemopoietic stem cell proliferation which we have labeled SCI/MIP-1 alpha. This inhibitor is also active on clonogenic epidermal cells and may thus be a more general stem cell inhibitor than was previously believed. The biology of this peptide is outlined in more detail below and the potential roles for such a factor in the developing embryo are also discussed.
造血系统是一个复杂的成年发育系统，可用于研究干细胞增殖控制和分化定向的机制。从这个模型系统中获得的信息可能对调节发育中的胚胎以及成年动物体内其他层级系统的控制过程具有启示意义。我们最近鉴定并分离出一种有效的造血干细胞增殖抑制剂，我们将其命名为SCI/MIP-1α。这种抑制剂对克隆性表皮细胞也有活性，因此可能是一种比以前认为的更具普遍性的干细胞抑制剂。下面将更详细地概述这种肽的生物学特性，并讨论这种因子在发育中的胚胎中的潜在作用。
