Konishi Y, Denda A, Uchida K, Emi Y, Ura H, Yokose Y, Shiraiwa K, Tsutsumi M
Department of Oncological Pathology, Nara Medical University, Japan.
Fundam Appl Toxicol. 1992 Jan;18(1):25-9. doi: 10.1016/0272-0590(92)90191-j.
The chronic toxicity and carcinogenic potential of triethanolamine was examined in B6C3F1 mice. Triethanolamine, dissolved in distilled water at levels of 0 (control), 1, and 2%, was given to groups of 50 males and 50 females ad libitum in drinking water for 82 weeks. Neoplasms developed in all groups, including the control group, but no dose-related increase of the incidence of any tumor was observed in treated groups of both sexes. There were no adverse effects as regards survival of the mice, organ weights, and specific incidence of neoplasms in the treated, compared to the control group. This chronic toxicity test provides no evidence of carcinogenic potential of triethanolamine in B6C3F1 mice.
在B6C3F1小鼠中检测了三乙醇胺的慢性毒性和致癌潜力。将三乙醇胺以0（对照组）、1%和2%的浓度溶解于蒸馏水中，分别给予每组50只雄性和50只雌性小鼠，让它们自由饮用含药饮水，持续82周。所有组，包括对照组，均出现了肿瘤，但在接受处理的两组中，未观察到任何肿瘤发生率与剂量相关的增加。与对照组相比，在处理组中，小鼠的存活、器官重量和特定肿瘤发生率均未出现不良反应。这项慢性毒性试验未提供三乙醇胺对B6C3F1小鼠具有致癌潜力的证据。
