Gutierrez-Espeleta G A, Hughes L A, Piegorsch W W, Shelby M D, Generoso W M
Biology Division, Oak Ridge National Laboratory, Tennessee 37738-8077.
Fundam Appl Toxicol. 1992 Feb;18(2):189-92.
Acrylamide is used extensively in sewage and wastewater treatment plants, in the paper and pulp industry, in treatment of potable water, and in research laboratories for chromatography, electrophoresis, and electron microscopy. Dermal contact is a major route of human exposure. It has been shown that acrylamide is highly effective in breaking chromosomes of germ cells of male mice and rats when administered intraperitoneally or orally, resulting both in the early death of conceptuses and in the transmission of reciprocal translocations to live-born progeny. It is now reported that acrylamide is absorbed through the skin of male mice, reaches the germ cells, and induces chromosomal damage. The magnitude of genetic damage appears to be proportional to the dose administered topically.
丙烯酰胺广泛应用于污水处理厂、造纸和纸浆工业、饮用水处理以及研究实验室中的色谱分析、电泳和电子显微镜等领域。皮肤接触是人类接触丙烯酰胺的主要途径。研究表明，当通过腹腔注射或口服给予雄性小鼠和大鼠丙烯酰胺时，它在破坏生殖细胞染色体方面非常有效，这既会导致胚胎早期死亡，也会将相互易位传递给存活的后代。现在有报道称，丙烯酰胺可通过雄性小鼠的皮肤吸收，到达生殖细胞，并诱导染色体损伤。遗传损伤的程度似乎与局部给药剂量成正比。
