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完全切除胰岛对南半球七鳃鳗(Geotria australis)血糖水平的影响。

Impact of complete isletectomy on plasma glucose in the southern hemisphere lamprey Geotria australis.

作者信息

Epple A, Cake M H, Potter I C, Tajbakhsh M

机构信息

Daniel Baugh Institute of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

出版信息

Gen Comp Endocrinol. 1992 May;86(2):284-8. doi: 10.1016/0016-6480(92)90112-w.

DOI:10.1016/0016-6480(92)90112-w
PMID:1601277
Abstract

The adult southern hemisphere lamprey Geotria australis is the only known vertebrate in which it is possible to remove all of the pancreatic islet tissue without damaging other organs. In the 24 hr after isletectomy, the plasma glucose of adult G. australis rose sharply from 5.0 to 11.6 mmol.liter-1 and remained at a similar elevated level throughout the subsequent 5 days of the experiment. The marked hyperglycemia that follows complete isletectomy parallels the results obtained after removal of the majority of the islet tissue from northern hemisphere lampreys and after pancreatectomy in mammals, but contrasts with observations recorded for some other groups of vertebrates.

摘要

成年南半球七鳃鳗(Geotria australis)是已知的唯一一种能够在不损害其他器官的情况下切除所有胰岛组织的脊椎动物。在胰岛切除术后的24小时内,成年南半球七鳃鳗的血浆葡萄糖水平从5.0毫摩尔/升急剧上升至11.6毫摩尔/升,并在随后实验的5天内一直维持在类似的较高水平。完全切除胰岛后出现的明显高血糖现象与从北半球七鳃鳗切除大部分胰岛组织后以及哺乳动物胰腺切除术后获得的结果相似,但与其他一些脊椎动物群体的观察结果形成对比。

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