Reyes Leonardo, Mañalich Reynaldo
Instituto de Nefrología, Ave 26 y Boyeros, Apdo. 6358, Havana 10600, Cuba.
Kidney Int Suppl. 2005 Aug(97):S107-11. doi: 10.1111/j.1523-1755.2005.09718.x.
There is accumulating evidence of the impact of low birth weight in adult age. Thus, the Barker theory and Brenner hypothesis gain more power. This article reviews and analyzes the evidence that supports the intrauterine origin of chronic noncommunicable diseases in adult age, particularly systemic arterial hypertension and chronic renal insufficiency. These are possibly related to lower nephron numbers, acquired in utero or later in life, which can increase susceptibility to kidney damage from diseases such as hypertension and diabetes mellitus, or cause arterial hypertension and secondary renal damage.
越来越多的证据表明低出生体重对成年期有影响。因此，巴克理论和布伦纳假说更具说服力。本文回顾并分析了支持成年期慢性非传染性疾病起源于子宫内的证据，特别是系统性动脉高血压和慢性肾功能不全。这些可能与子宫内或生命后期获得的肾单位数量减少有关，这会增加对高血压和糖尿病等疾病所致肾损伤的易感性，或导致动脉高血压和继发性肾损伤。
