Amato Dante, Alvarez-Aguilar Cleto, Castañeda-Limones Rutila, Rodriguez Ernesto, Avila-Diaz Marcela, Arreola Francisco, Gomez Anel, Ballesteros Hiram, Becerril Raquel, Paniagua Ramon
Unidad de Investigacion Medica en Enfermedades Nefrologicas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Suguro Social, Av. Cuauhtemoc 330, Colonia Doctores, Mexico City 06725, Mexico.
Kidney Int Suppl. 2005 Aug(97):S11-7. doi: 10.1111/j.1523-1755.2005.09702.x.
The present study was primarily designed to assess the prevalence of chronic kidney disease in a Mexican urban population residing in Mexico and to evaluate certain biologic and socioeconomic conditions as risk factors for the development of renal disease.
A population-based cross-sectional survey was conducted, which included 3564 patients of either gender aged >18 years, who were randomly selected from lists of patients assigned to primary care facilities in the city of Morelia. A questionnaire about personal current health status, kidney disease, diabetes, hypertension, or heart disease in close relatives, anthropometric and blood pressure measurements, and blood and urine samples to measure glucose, blood urea nitrogen, and creatinine was obtained for each patient. Creatinine clearance (Ccr) was calculated by the Cockcroft-Gault formula. Patients were classified in 1 of the 5 Ccr categories established by the Kidney Disease Outcomes Quality Initiative guidelines.
The prevalence rate of Ccr < 15 mL/min was 1142 per million population, and that of Ccr <60 mL/min 80,788 per million population. Alcohol and tobacco consumption, female gender, age >65 years, educational level < primary school, and income < US $4.00/day were significantly associated with reduced Ccr.
Chronic kidney disease prevalence in this population is similar to that seen in industrialized countries. If these figures are similar to those of the entire Mexican population, only l out of 4 patients requiring renal replacement therapy in the country currently has access to it.
本研究主要旨在评估居住在墨西哥的墨西哥城市人口中慢性肾脏病的患病率,并评估某些生物学和社会经济状况作为肾病发展的危险因素。
进行了一项基于人群的横断面调查,纳入了3564名年龄大于18岁的男女患者,这些患者是从莫雷利亚市初级保健机构分配的患者名单中随机选取的。为每位患者获取了一份关于个人当前健康状况、肾病、糖尿病、高血压或近亲中的心脏病的问卷、人体测量和血压测量结果,以及用于测量血糖、血尿素氮和肌酐的血液和尿液样本。肌酐清除率(Ccr)通过Cockcroft-Gault公式计算。患者根据肾脏疾病改善全球预后(KDIGO)指南确定的5个Ccr类别之一进行分类。
Ccr<15 mL/分钟的患病率为每百万人口1142例,Ccr<60 mL/分钟的患病率为每百万人口80788例。饮酒和吸烟、女性、年龄>65岁、教育水平<小学以及收入<4.00美元/天与Ccr降低显著相关。
该人群中慢性肾脏病的患病率与工业化国家相似。如果这些数字与整个墨西哥人口的数字相似,那么该国目前每4名需要肾脏替代治疗的患者中只有1名能够获得这种治疗。