Mellerup Martin T, Bruun Niels Eske, Nielsen Jørn Dalsgaard
Klinisk-Biokemisk Afdeling, Amtssygehuset i Gentofte, Københavns Amts Trombosecenter.
Ugeskr Laeger. 2005 Jun 20;167(25-31):2790-1.
Bleeding induced by beta-lactam antibiotics was reported for the first time in 1970. The phenomenon has been confirmed in subsequent studies but has never resulted in any general recommendations for, e.g., screening and treatment. Over a period of seven months, we diagnosed in our department three cases of presumed beta-lactam-induced bleeding in patients treated with high-dose penicillin for endocarditis and septic shock.
1970年首次报道了β-内酰胺类抗生素引起的出血现象。该现象在随后的研究中得到了证实，但从未产生过任何一般性的建议，例如筛查和治疗建议。在七个月的时间里，我们科室诊断出三例在用大剂量青霉素治疗心内膜炎和感染性休克的患者中疑似β-内酰胺类抗生素引起的出血病例。
