自身抗原为何成为自身抗原？

What makes an autoantigen an autoantigen?

作者信息

Wu Chih-Te, Gershwin M Eric, Davis Paul A

机构信息

Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine, GBSF Suite 6510, 451 E. Health Sciences Drive, University of California, Davis, CA 95616, USA.

出版信息

Ann N Y Acad Sci. 2005 Jun;1050:134-45. doi: 10.1196/annals.1313.015.

DOI:10.1196/annals.1313.015

PMID:16014528

Abstract

Multiple classes of proteins are modified to tailor them for specific physiological roles. The nature of these posttranslational modifications of proteins, as well as the relationships between them including those of the immune system proteins themselves, and immune system responses are reviewed. Aspects of protein posttranslational modification and their relationship to the pathogenesis of several autoimmune diseases and primary biliary cirrhosis are highlighted.

摘要

多种蛋白质类别会被修饰，以使其适应特定的生理功能。本文综述了蛋白质这些翻译后修饰的性质，以及它们之间的关系，包括免疫系统蛋白质自身之间的关系，还有免疫系统反应。重点介绍了蛋白质翻译后修饰的各个方面及其与几种自身免疫性疾病和原发性胆汁性肝硬化发病机制的关系。