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本文引用的文献

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Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction.系统性红斑狼疮患者的血清淀粉样蛋白P成分水平并未降低，且在急性期反应期间也不会升高。
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2
Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?血清淀粉样蛋白P成分基因靶向缺失小鼠的自身免疫与肾小球肾炎：是SAP缺乏还是品系组合？
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Clinically active serologically quiescent systemic lupus erythematosus.临床活动但血清学静止的系统性红斑狼疮
J Rheumatol. 2003 Sep;30(9):1960-2.
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Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages.血清淀粉样蛋白P成分与晚期凋亡细胞结合，并介导单核细胞衍生的巨噬细胞对其摄取。
Arthritis Rheum. 2003 Jan;48(1):248-54. doi: 10.1002/art.10737.
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Structural, quantitative and functional comparison of amyloid P component in sera from patients with systemic lupus erythematosus and healthy donors.系统性红斑狼疮患者与健康供体血清中淀粉样蛋白P成分的结构、定量及功能比较
Scand J Immunol. 2002 Dec;56(6):645-51. doi: 10.1046/j.1365-3083.2002.01178.x.
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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.靶向性药物清除血清淀粉样蛋白P成分用于治疗人类淀粉样变性病。
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Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus.系统性红斑狼疮患者生发中心中凋亡细胞向可染小体巨噬细胞的摄取受损。
Arthritis Rheum. 2002 Jan;46(1):191-201. doi: 10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO;2-K.
8
Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease.缺乏血清淀粉样蛋白P成分的小鼠不一定会患上严重的自身免疫性疾病。
Biochem Biophys Res Commun. 2001 Aug 10;286(1):200-5. doi: 10.1006/bbrc.2001.5364.
9
Chromatin-independent binding of serum amyloid P component to apoptotic cells.血清淀粉样蛋白P成分与凋亡细胞的非染色质依赖性结合。
J Immunol. 2001 Jul 15;167(2):647-54. doi: 10.4049/jimmunol.167.2.647.
10
Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.血清淀粉样蛋白P成分与Fcγ受体结合，并调理颗粒以便吞噬。
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系统性红斑狼疮患者体内的抗血清淀粉样蛋白P成分抗体与疾病活动度相关。

Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity.

作者信息

Zandman-Goddard G, Blank M, Langevitz P, Slutsky L, Pras M, Levy Y, Shovman O, Witte T, Doria A, Rovensky J, Shoenfeld Y

机构信息

Centre for Autoimmune Diseases and Department of Medicine B, Sheba Medical Centre, Tel Hashomer, Israel 52621.

出版信息

Ann Rheum Dis. 2005 Dec;64(12):1698-702. doi: 10.1136/ard.2005.035832. Epub 2005 Jul 13.

DOI:10.1136/ard.2005.035832
PMID:16014675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1755319/
Abstract

OBJECTIVE

To determine the presence of raised titres of anti-serum amyloid P component (SAP) antibodies in patients with systemic lupus erythematosus (SLE) and to evaluate their correlation with clinical disease by the SLEDAI and clinical manifestations.

METHODS

452 samples were screened for raised anti-SAP antibody titres by an ELISA. Clinical measures and SLEDAI scores were independently reviewed from medical records. 21 serial samples from 7 patients with SLE were assessed for a change in anti-SAP antibody titres after treatment.

RESULTS

Raised anti-SAP antibody titres were detected in 145/328 (44%) SLE samples. In 112 randomly selected samples, 69/112 (62%) patients had raised anti-SAP antibodies and anti-dsDNA antibody titres, whereas only 32/112 (28%) had raised anti-dsDNA antibody titres without raised anti-SAP antibody titres. The mean titre of anti-SAP antibodies in patients with active disease was higher than in patients with inactive disease and controls. SLEDAI scores, assessed in 54 patients, were raised in 26/31 (84%) patients with raised anti-SAP antibody titres. A SLEDAI score >or=8 was found in 16/31 (52%) patients with raised anti-SAP antibody titres but in only 5/23 (22%) patients without raised titres. No specific pattern of disease was detected in patients with or without raised titres of anti-SAP antibodies. Serial sampling from patients with active SLE and raised anti-SAP antibody titres showed that anti-SAP antibody titres decreased after treatment and correlated with clinical improvement.

CONCLUSION

Raised anti-SAP antibody titres detected in patients with SLE correlate with disease activity and decrease with improvement of clinical disease, and thus may serve as an additional prognostic marker.

摘要

目的

确定系统性红斑狼疮（SLE）患者中抗血清淀粉样蛋白P成分（SAP）抗体滴度升高的情况，并通过SLE疾病活动指数（SLEDAI）和临床表现评估其与临床疾病的相关性。

方法

采用酶联免疫吸附测定（ELISA）法对452份样本进行抗SAP抗体滴度升高的筛查。从病历中独立回顾临床指标和SLEDAI评分。对7例SLE患者的21份连续样本进行治疗后抗SAP抗体滴度变化的评估。

结果

在328份SLE样本中，145份（44%）检测到抗SAP抗体滴度升高。在112份随机选择的样本中，69/112（62%）例患者抗SAP抗体和抗双链DNA（dsDNA）抗体滴度升高，而只有32/112（28%）例患者抗dsDNA抗体滴度升高但抗SAP抗体滴度未升高。活动期疾病患者的抗SAP抗体平均滴度高于非活动期疾病患者和对照组。在54例患者中评估SLEDAI评分，31例抗SAP抗体滴度升高的患者中有26例（84%）SLEDAI评分升高。抗SAP抗体滴度升高的31例患者中有16例（52%）SLEDAI评分≥8，而抗SAP抗体滴度未升高的23例患者中只有5例（22%）SLEDAI评分≥8。抗SAP抗体滴度升高或未升高的患者均未检测到特定的疾病模式。对活动期SLE且抗SAP抗体滴度升高的患者进行连续采样显示，治疗后抗SAP抗体滴度下降且与临床改善相关。

结论

SLE患者中检测到的抗SAP抗体滴度升高与疾病活动相关，且随临床疾病改善而下降，因此可能作为一种额外的预后标志物。