Varki Ajit, Angata Takashi
Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8568, Japan.
Glycobiology. 2006 Jan;16(1):1R-27R. doi: 10.1093/glycob/cwj008. Epub 2005 Jul 13.
Animal glycan-recognizing proteins can be broadly classified into two groups-lectins (which typically contain an evolutionarily conserved carbohydrate-recognition domain [CRD]) and sulfated glycosaminoglycan (SGAG)-binding proteins (which appear to have evolved by convergent evolution). Proteins other than antibodies and T-cell receptors that mediate glycan recognition via immunoglobulin (Ig)-like domains are called "I-type lectins." The major homologous subfamily of I-type lectins with sialic acid (Sia)-binding properties and characteristic amino-terminal structural features are called the "Siglecs" (Sia-recognizing Ig-superfamily lectins). The Siglecs can be divided into two groups: an evolutionarily conserved subgroup (Siglecs-1, -2, and -4) and a CD33/Siglec-3-related subgroup (Siglecs-3 and -5-13 in primates), which appear to be rapidly evolving. This article provides an overview of historical and current information about the Siglecs.
动物聚糖识别蛋白大致可分为两类——凝集素（通常含有一个进化上保守的碳水化合物识别结构域[CRD]）和硫酸化糖胺聚糖（SGAG）结合蛋白（它们似乎是通过趋同进化而形成的）。除抗体和T细胞受体外，通过免疫球蛋白（Ig）样结构域介导聚糖识别的蛋白质被称为“I型凝集素”。具有唾液酸（Sia）结合特性和特征性氨基末端结构特征的I型凝集素的主要同源亚家族被称为“Siglec”（识别Sia的Ig超家族凝集素）。Siglec可分为两组：进化上保守的亚组（Siglec-1、-2和-4）和CD33/Siglec-3相关亚组（灵长类动物中的Siglec-3和-5-13），后者似乎在快速进化。本文概述了关于Siglec的历史和当前信息。
