Crocker Paul R
The Wellcome Trust Biocentre at Dundee, Division of Cell Biology and Immunology, School of Life Sciences, Dundee University, Dow Street, Dundee DD1 5EH, Scotland, UK.
Curr Opin Struct Biol. 2002 Oct;12(5):609-15. doi: 10.1016/s0959-440x(02)00375-5.
Siglecs are sialic-acid-binding immunoglobulin-like lectins involved in cell-cell interactions and signalling functions in the haemopoietic, immune and nervous systems. Significant advances have been made in our understanding of the link between carbohydrate recognition and signalling for two well-characterised siglecs, CD22 and myelin-associated glycoprotein. Over the past few years, several novel siglecs have been discovered through genomics and functional screens. These "CD33-related" siglecs have molecular features of inhibitory receptors and may be important in regulating leucocyte activation during immune and inflammatory responses.
唾液酸结合免疫球蛋白样凝集素（Siglecs）参与造血、免疫和神经系统中的细胞间相互作用及信号传导功能。在我们对两种特征明确的Siglecs，即CD22和髓鞘相关糖蛋白的碳水化合物识别与信号传导之间联系的理解上取得了重大进展。在过去几年中，通过基因组学和功能筛选发现了几种新型Siglecs。这些“CD33相关”的Siglecs具有抑制性受体的分子特征，可能在免疫和炎症反应期间调节白细胞激活中起重要作用。
