心脏保护作用：β受体阻滞剂治疗的作用
Cardioprotection: the role of beta-blocker therapy.
作者信息
Egan Brent M, Basile Jan, Chilton Robert J, Cohen Jerome D
机构信息
Medical University of South Carolina, Charleston, 29425, USA.
出版信息
J Clin Hypertens (Greenwich). 2005 Jul;7(7):409-16. doi: 10.1111/j.1524-6175.2005.04486.x.
Abstract
Randomized controlled clinical trials document that beta blockers reduce cardiovascular morbidity and mortality, particularly sudden death, in patients with hypertension, heart failure, and post-myocardial infarction. The benefits of beta blockers extend across the boundaries of age, gender, and ethnicity, and include diabetic patients with heart failure and/or previous myocardial infarction. Unfortunately, beta blockers remain underutilized in many high-risk patients who would likely benefit from their use. This paper reviews the protective role of beta blockade in the primary and secondary prevention of cardiovascular events and examines some of the potential barriers to appropriate beta blocker use in patients with compelling indications.
摘要
随机对照临床试验证明，β受体阻滞剂可降低高血压、心力衰竭和心肌梗死后患者的心血管发病率和死亡率，尤其是猝死率。β受体阻滞剂的益处不受年龄、性别和种族的限制，包括患有心力衰竭和/或既往心肌梗死的糖尿病患者。不幸的是，β受体阻滞剂在许多可能受益于其使用的高危患者中仍未得到充分利用。本文综述了β受体阻滞剂在心血管事件一级和二级预防中的保护作用，并探讨了在有明确适应证的患者中合理使用β受体阻滞剂的一些潜在障碍。
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本文引用的文献
1
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
JAMA. 2003 May 21;289(19):2560-72. doi: 10.1001/jama.289.19.2560. Epub 2003 May 14.
2
Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender, and diabetic status: a meta-analysis of major clinical trials.
J Am Coll Cardiol. 2003 May 7;41(9):1529-38. doi: 10.1016/s0735-1097(03)00262-6.
3
beta-Blockers and reduction of cardiac events in noncardiac surgery: clinical applications.
JAMA. 2002 Mar 20;287(11):1445-7. doi: 10.1001/jama.287.11.1445.
4
ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure).
J Am Coll Cardiol. 2001 Dec;38(7):2101-13. doi: 10.1016/s0735-1097(01)01683-7.
5
AHA/ACC Scientific Statement: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update: A statement for healthcare professionals from the American Heart Association and the American College of Cardiology.
Circulation. 2001 Sep 25;104(13):1577-9. doi: 10.1161/hc3801.097475.
6
Task Force on Sudden Cardiac Death of the European Society of Cardiology.
Eur Heart J. 2001 Aug;22(16):1374-450. doi: 10.1053/euhj.2001.2824.
7
Effect of carvedilol on survival in severe chronic heart failure.
N Engl J Med. 2001 May 31;344(22):1651-8. doi: 10.1056/NEJM200105313442201.
8
Beta-blockers in congestive heart failure. A Bayesian meta-analysis.
Ann Intern Med. 2001 Apr 3;134(7):550-60. doi: 10.7326/0003-4819-134-7-200104030-00008.
9
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF).
Lancet. 1999 Jun 12;353(9169):2001-7.
10
ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina).
Circulation. 1999 Jun 1;99(21):2829-48. doi: 10.1161/01.cir.99.21.2829.
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