Siddiqui R A, McCutcheon S N, Blair H T, Mackenzie D D, Morel P C, Breier B H, Gluckman P D
Department of Pediatrics, University of Auckland Medical School, New Zealand.
Growth Dev Aging. 1992 Spring;56(1):53-60.
Growth allometry was examined over the range 6 to 112 days of age in male and female mice from lines selected for low (L) or high (H) plasma concentrations of insulin-like growth factor-I (IGF-I). Plasma IGF-I concentrations were greater in the H line than in L line mice from 28 days of age. H line mice also had greater liveweights and weights of the heart, kidneys, pancreas, lungs, liver, brain and testes from 21-28 days of age. Changes in weights of these organs reflected the general pattern of body growth, there being no consistent effects of selection line on allometric growth coefficients. Ovarian weights were not different between the lines. For muscle weights, (gastrocnemius, quadriceps femoris), the weights or lengths of bones (tibia, femur) and the nose-anus and anus-tail lengths, allometric growth coefficients were generally higher (P less than .05) in L line females than in L line males or H line mice of either sex. The allometric growth coefficient for spleen was significantly (P less than .05) greater in H line mice than in L line mice with the result that spleen weights were 30% higher in H line mice from 28 days of age. This is consistent with results from mice treated with, or transgenic for, IGF-I and suggests a specific effect of this hormone on growth of the spleen. Thymus weights were also greater in H line than in L line mice and developmental patterns of thymus weight closely paralleled those of circulating IGF-I.
对从胰岛素样生长因子-I（IGF-I）血浆浓度低（L）或高（H）品系中选取的雄性和雌性小鼠在6至112日龄范围内的生长异速生长进行了研究。从28日龄起，H品系小鼠的血浆IGF-I浓度高于L品系小鼠。从21至28日龄起，H品系小鼠的心脏、肾脏、胰腺、肺、肝脏、大脑和睾丸的活体重量和重量也更大。这些器官重量的变化反映了身体生长的总体模式，选择品系对异速生长系数没有一致的影响。品系间卵巢重量没有差异。对于肌肉重量（腓肠肌、股四头肌）、骨骼重量或长度（胫骨、股骨）以及鼻-肛门和肛门-尾长度，L品系雌性小鼠的异速生长系数通常高于（P<0.05）L品系雄性小鼠或任何性别的H品系小鼠。H品系小鼠脾脏的异速生长系数显著高于（P<0.05）L品系小鼠，结果从28日龄起，H品系小鼠的脾脏重量高出30%。这与用IGF-I处理或转染IGF-I的小鼠的结果一致，并表明该激素对脾脏生长有特定作用。H品系小鼠的胸腺重量也高于L品系小鼠，胸腺重量的发育模式与循环IGF-I的发育模式密切平行。
