Hart W T, Hallenborg C P
Department of Medicine, John A Burns School of Medicine.
Hawaii Med J. 1992 May;51(5):121, 125, 134.
Disseminated intravascular coagulation (DIC) can be defined as evidence of activation of the coagulation mechanism resulting in proteolysis of fibrinogen by thrombin and plasmin and an acute thrombocytopenia. The association of pulmonary embolism (PE) with DIC has recently been reported but in reviewing recent textbooks of hematology, there is no mention of PE as a cause of DIC. Clinicians need to be made aware of this association since it affects the patient who is thought to be autoanticoagulated as well as the patient who has DIC of unknown cause. PE needs to be included in the differential diagnosis of an autoanticoagulated state and in DIC of unknown etiology. In both instances the recommended treatment is full-dose intravenous heparin therapy.
弥散性血管内凝血（DIC）可定义为凝血机制激活的证据，其导致凝血酶和纤溶酶对纤维蛋白原进行蛋白水解，并伴有急性血小板减少。最近有报道称肺栓塞（PE）与DIC有关，但在查阅近期的血液学教科书时，未提及PE是DIC的病因。临床医生需要了解这种关联，因为它会影响被认为处于自身抗凝状态的患者以及病因不明的DIC患者。在自身抗凝状态的鉴别诊断和病因不明的DIC中，都需要考虑PE。在这两种情况下，推荐的治疗方法都是全剂量静脉肝素治疗。
