用于酮不对称还原的可回收氟代CBS方法。

Recoverable fluorous CBS methodology for asymmetric reduction of ketones.

作者信息

Dalicsek Zoltán, Pollreisz Ferenc, Gömöry Agnes, Soós Tibor

机构信息

Institute of Biomolecular Chemistry, Chemical Research Center of Hungarian Academy of Science, Budapest.

出版信息

Org Lett. 2005 Jul 21;7(15):3243-6. doi: 10.1021/ol051024j.

DOI:10.1021/ol051024j

PMID:16018631

Abstract

[reaction: see text]. An operationally simple and recoverable fluorous CBS methodology was developed. The in situ-generated fluorous oxazaborolidine efficiently catalyzed the reduction of ketones with high enantioselectivity and reactivity. The subsequent recycling of the fluorous prolinol precatalyst was achieved by fluorous solid-phase extraction.

摘要

[反应：见正文]。开发了一种操作简单且可回收的氟代CBS方法。原位生成的氟代恶唑硼烷能高效催化酮的还原反应，具有高对映选择性和反应活性。通过氟代固相萃取实现了氟代脯氨醇前催化剂的后续循环利用。