糖尿病合并急性心肌梗死患者慢性与急性血糖控制与死亡率的关系。

Relation of chronic and acute glycemic control on mortality in acute myocardial infarction with diabetes mellitus.

作者信息

Cao Jie J, Hudson Michael, Jankowski Michelle, Whitehouse Fred, Weaver W Douglas

机构信息

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Am J Cardiol. 2005 Jul 15;96(2):183-6. doi: 10.1016/j.amjcard.2005.03.040.

DOI:10.1016/j.amjcard.2005.03.040

PMID:16018838

Abstract

Acute hyperglycemia during myocardial infarction predicts adverse short-term outcomes and mortality in diabetic patients. Conversely, chronic hyperglycemia is associated with an increased incidence of long-term cardiovascular complications, although its effect on acute hyperglycemic response and mortality after acute myocardial infarction is unknown. We investigated the prognostic relation of the glucose concentration at admission and the baseline average glycohemoglobin on acute myocardial infarction mortality. Of 808 consecutive diabetic patients with acute myocardial infarction, the most significant independent predictor of in-hospital mortality was the glucose concentration at admission. Baseline glycohemoglobin strongly correlated with admission hyperglycemia but did not predict mortality independently.

摘要

心肌梗死期间的急性高血糖可预测糖尿病患者的不良短期结局和死亡率。相反，慢性高血糖与长期心血管并发症的发生率增加相关，尽管其对急性心肌梗死后急性高血糖反应和死亡率的影响尚不清楚。我们研究了入院时血糖浓度和基线平均糖化血红蛋白与急性心肌梗死死亡率的预后关系。在808例连续的急性心肌梗死糖尿病患者中，入院时血糖浓度是院内死亡率最显著的独立预测因素。基线糖化血红蛋白与入院时高血糖密切相关，但不能独立预测死亡率。