Boudet C, Bocca M L, Chabot B, Delamillieure P, Brazo P, Denise P, Dollfus S
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000 Caen, France.
Eur Psychiatry. 2005 Jun;20(4):339-45. doi: 10.1016/j.eurpsy.2004.12.010.
Fifty to eighty-five percent of schizophrenic patients are impaired on ocular pursuit paradigms. However, results regarding the relatives are more discordant. The aim of this study was to investigate whether eye movement disorders could be a vulnerability marker of schizophrenia.
Twenty-one schizophrenic patients (DSM-IV), 31 first-degree relatives of those patients without schizophrenic spectrum disorders, and two groups of healthy controls matched by age and sex were included. Three oculomotor tasks (smooth pursuit, reflexive saccades and antisaccades) were used.
Patients had a lower averaged gain (P= 0.035) during smooth pursuit than controls, made less correct visually guided saccades (P< 0.001) and more antisaccades errors (P= 0.002) than controls. In contrast, none of the comparison between the relatives and their controls was significant.
Schizophrenic patients were impaired on smooth pursuit and antisaccade paradigms. None of these impairments was, however, observed in their first-degree relatives. Our results suggest that the eye movement parameters tested could not be considered as vulnerability markers for schizophrenia.
50%至85%的精神分裂症患者在眼球追踪范式测试中表现受损。然而，关于其亲属的测试结果则更不一致。本研究旨在调查眼球运动障碍是否可能是精神分裂症的易感性标志物。
纳入21名精神分裂症患者（符合DSM-IV标准）、31名无精神分裂症谱系障碍的患者一级亲属以及两组年龄和性别匹配的健康对照者。采用三项眼球运动任务（平稳追踪、反射性扫视和反扫视）。
患者在平稳追踪过程中的平均增益低于对照组（P = 0.035），在视觉引导下做出的正确扫视比对照组少（P < 0.001），反扫视错误比对照组多（P = 0.002）。相比之下，亲属与其对照组之间的所有比较均无显著差异。
精神分裂症患者在平稳追踪和反扫视范式测试中表现受损。然而，在他们的一级亲属中未观察到这些损害。我们的结果表明，所测试的眼球运动参数不能被视为精神分裂症的易感性标志物。
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