酒精依赖与腹侧纹状体中多巴胺传递减弱有关。

Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum.

作者信息

Martinez Diana, Gil Roberto, Slifstein Mark, Hwang Dah-Ren, Huang Yiyun, Perez Audrey, Kegeles Lawrence, Talbot Peter, Evans Suzette, Krystal John, Laruelle Marc, Abi-Dargham Anissa

机构信息

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA.

出版信息

Biol Psychiatry. 2005 Nov 15;58(10):779-86. doi: 10.1016/j.biopsych.2005.04.044. Epub 2005 Jul 14.

DOI:10.1016/j.biopsych.2005.04.044

PMID:16018986

Abstract

BACKGROUND

A decrease in dopamine type 2 receptors (D2) and mesolimbic dopamine transmission predisposes animals to consume alcohol. This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride.

METHODS

Fifteen AD and 15 healthy control (HC) subjects were scanned before and after a psychostimulant challenge (amphetamine .3 mg/kg intravenous). The outcome measures for baseline D2 receptor availability were binding potential (BP) and the equilibrium partition coefficient (V3''). Amphetamine-induced [11C]raclopride displacement was measured as the difference in V3'' between the two scans.

RESULTS

[11C]raclopride BP was significantly reduced by 16.6% in the limbic striatum, 19.2% in the associative striatum, and 21.3% in the sensorimotor striatum in AD subjects compared with HC. The alcohol-dependent subjects showed a blunting of amphetamine-induced dopamine release in the limbic striatum: [11C]raclopride displacement was -5.2% +/- 3.6% in AD subjects compared with -13.0% +/- 8.8% in HC. However, no significant difference in [11C]raclopride displacement was seen in the associative (-4.6% +/- 5.8% in AD subjects vs. -6.7 +/- 5.4% in HC) and sensorimotor (-12.3% +/- 7.3% in AD subjects vs. -13.7 +/- 7.5% in HC) subdivisions of the striatum between the two groups.

CONCLUSIONS

Alcohol dependence was associated with a decrease in D2 receptors in each striatal subdivision, whereas amphetamine-induced dopamine release was reduced in the limbic striatum only.

摘要

背景

多巴胺2型受体（D2）减少和中脑边缘多巴胺传递会使动物易饮酒。本研究使用正电子发射断层扫描（PET）和[11C]雷氯必利测量了酒精依赖（AD）患者的D2受体和多巴胺传递。

方法

对15名AD患者和15名健康对照（HC）受试者在精神兴奋剂激发试验（静脉注射苯丙胺0.3mg/kg）前后进行扫描。基线D2受体可用性的结果指标为结合潜能（BP）和平衡分配系数（V3''）。苯丙胺诱导的[11C]雷氯必利位移通过两次扫描之间V3''的差异来测量。

结果

与HC相比，AD受试者边缘纹状体中[11C]雷氯必利BP显著降低16.6%，联合纹状体中降低19.2%，感觉运动纹状体中降低21.3%。酒精依赖受试者边缘纹状体中苯丙胺诱导的多巴胺释放减弱：AD受试者中[11C]雷氯必利位移为-5.2%±3.6%，而HC中为-13.0%±8.8%。然而，两组之间在联合纹状体（AD受试者中为-4.6%±5.8%，HC中为-6.7±5.4%）和感觉运动纹状体（AD受试者中为-12.3%±7.3%，HC中为-13.7±7.5%）的[11C]雷氯必利位移上未观察到显著差异。