Turton Samuel, Paterson Louise M, Myers James Fm, Mick Inge, Lan Chen-Chia, McGonigle John, Bowden-Jones Henrietta, Clark Luke, Nutt David J, Lingford-Hughes Anne R
Division of Psychiatry, Imperial College London, London, UK.
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London UK.
Neuroimage Rep. 2024 Sep;4(3):100211. doi: 10.1016/j.ynirp.2024.100211.
Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. AD and GD are associated with dysregulated responses to reward which could be due to a common mechanism of dysregulated endogenous opioid signalling. We explored associations between reward anticipation responses, using the Monetary Incentive Delay (MID) functional magnetic resonance imaging (fMRI) task, and mu-opioid receptor (MOR) availability and endogenous opioid release capacity using [C]carfentanil positron emission tomography (PET), in 13 AD, 15 GD and 14 heathy control (HC) participants. We also examined differences in MID task reward anticipation responses between AD, GD and HC participants. These were secondary exploratory analysis of data collected to examine differences in MOR PET in addiction. We did not find significant differences in MID win > neutral anticipation BOLD responses compared between participant groups in a priori ROIs (ventral striatum, putamen, caudate) or whole brain analyses. We found no significant correlations between MID win > neutral anticipation BOLD responses and [C]carfentanil PET measures, except for limited negative correlations between putamen MOR availability and MID win > neutral anticipation BOLD response in AD participants. Previous research has suggested a limited role of endogenous opioid signalling on MID task reward anticipation responses in AD and HCs as these responses are not modulated by opioid receptor blockade and this may explain our lack of significant correlations in HC and AD or GD participants. Our results, particularly the lack of differences in MID win > neutral anticipation BOLD responses across participants groups, may be limited due to only including AD or GD participants who are abstinent or in active treatment.
酒精依赖（AD）和赌博障碍（GD）是常见的成瘾性疾病，会对身心健康造成重大影响。AD和GD与奖赏反应失调有关，这可能是由于内源性阿片类信号传导失调的共同机制所致。我们使用货币激励延迟（MID）功能磁共振成像（fMRI）任务，研究了奖赏预期反应与μ-阿片受体（MOR）可用性以及内源性阿片类物质释放能力之间的关联，其中内源性阿片类物质释放能力通过[C]卡芬太尼正电子发射断层扫描（PET）来测定，研究对象包括13名AD患者、15名GD患者和14名健康对照（HC）参与者。我们还检查了AD、GD和HC参与者在MID任务奖赏预期反应方面的差异。这些是对收集的数据进行的二次探索性分析，目的是研究成瘾中MOR PET的差异。我们在先验感兴趣区域（腹侧纹状体、壳核、尾状核）或全脑分析中比较参与者组时，未发现MID赢>中性预期的血氧水平依赖（BOLD）反应有显著差异。我们发现MID赢>中性预期的BOLD反应与[C]卡芬太尼PET测量值之间没有显著相关性，但AD参与者的壳核MOR可用性与MID赢>中性预期的BOLD反应之间存在有限的负相关。先前的研究表明，内源性阿片类信号传导在AD和HC的MID任务奖赏预期反应中作用有限，因为这些反应不受阿片受体阻断的调节，这可能解释了我们在HC、AD或GD参与者中缺乏显著相关性的原因。我们的结果，特别是各参与者组之间MID赢>中性预期的BOLD反应缺乏差异，可能由于仅纳入了戒酒或正在接受积极治疗的AD或GD参与者而受到限制。
