Védrine L, Bauduceau O, Fayolle M, Le Moulec S, Ceccaldi B
Service d'oncologie médicale et radiothérapie, hôpital d'instruction des armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75230 Paris cedex 05, France.
Cancer Radiother. 2005 Sep;9(5):335-40. doi: 10.1016/j.canrad.2005.06.004. Epub 2005 Jul 12.
Optimal management of intracranial germinomas remains controversial. Focal irradiation to the primary tumor followed by prophylactic craniospinal radiotherapy represents the traditional treatment resulting in excellent long-term survival but potential late effects. To decrease late effects related to extensive fields of radiotherapy, combined chemotherapy and irradiation has been tested with reduced volumes and doses of radiation therapy. We report our experience about four patients successfully treated by neoadjuvant chemotherapy with carboplatin and etoposide followed by radiotherapy delivering 26 to 36 Gy to the whole brain and 36 to 50 Gy to the initial tumor volume.
颅内生殖细胞瘤的最佳治疗方案仍存在争议。对原发肿瘤进行局部照射，随后进行预防性全脑脊髓放疗是传统的治疗方法，可带来良好的长期生存率，但存在潜在的晚期效应。为了减少与广泛放疗区域相关的晚期效应，已对联合化疗和放疗进行了试验，减少了放疗的体积和剂量。我们报告了4例患者的治疗经验，这些患者先接受卡铂和依托泊苷新辅助化疗，随后进行放疗，全脑放疗剂量为26至36 Gy，初始肿瘤体积放疗剂量为36至50 Gy，治疗均获成功。
