氟达拉滨治疗慢性淋巴细胞白血病后出现特发性血小板减少性紫癜和重症肌无力。

Idiopathic thrombocytopenic purpura and myasthenia gravis after fludarabine treatment for chronic lymphocytic leukemia.

作者信息

Fujimaki Katsumichi, Takasaki Hirotaka, Koharazawa Hideyuki, Takabayashi Maki, Yamaji Satoshi, Baba Yasuhisa, Kanamori Heiwa, Ishigatsubo Yoshiaki

机构信息

First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.

出版信息

Leuk Lymphoma. 2005 Jul;46(7):1101-2. doi: 10.1080/10428190500063054.

DOI:10.1080/10428190500063054

PMID:16019566

Abstract

We report a patient with chronic lymphocytic leukemia (CLL) who developed idiopathic thrombocytopenic purpura (ITP) and myasthenia gravis (MG) after fludarabine therapy. ITP developed after 6 cycles of fludarabine treatment, and MG occurred 2 months after the onset of ITP. MG was successfully treated with immunosuppressive therapy and plasma exchange, while rituximab was effective for CLL and ITP. Fludarabine seemed to have an important role in the onset of ITP and MG in this case.

摘要

我们报告了1例慢性淋巴细胞白血病（CLL）患者，其在接受氟达拉滨治疗后发生了特发性血小板减少性紫癜（ITP）和重症肌无力（MG）。ITP在氟达拉滨治疗6个周期后发生，MG在ITP发病2个月后出现。MG通过免疫抑制治疗和血浆置换成功治愈，而利妥昔单抗对CLL和ITP有效。在该病例中，氟达拉滨似乎在ITP和MG的发病中起重要作用。