Dane Senol, Timur Handan
Department of Physiology, Medical School, Atatürk University, Erzurum, Turkey.
Int J Neurosci. 2005 Jun;115(6):911-6. doi: 10.1080/00207450590882190.
Earlier studies reported the associations among testosterone hormone, autoimmunity, and left-handedness. In the present study, sex differences in tuberculin reaction, a measure of cell-mediated hypersensitivity, serum free and total testosterone levels in controls and patients with autoimmune diseases were studied. There was a sex difference in right and left tuberculin reactions in controls, but not in patients. Both right and left tuberculin reactions were smaller in male and female patients than male and female controls. Free and total testosterone levels were higher in male controls than in male patients. Total testosterone levels were higher in female controls than in female patients. These results suggest that autoimmune diseases may be associated with a decrease in the blood testosterone concentrations.
早期研究报告了睾酮激素、自身免疫和左利手之间的关联。在本研究中，对对照组和自身免疫性疾病患者的结核菌素反应（一种细胞介导的超敏反应指标）、血清游离睾酮和总睾酮水平的性别差异进行了研究。对照组左右结核菌素反应存在性别差异，但患者中不存在。男性和女性患者的左右结核菌素反应均小于男性和女性对照组。男性对照组的游离睾酮和总睾酮水平高于男性患者。女性对照组的总睾酮水平高于女性患者。这些结果表明，自身免疫性疾病可能与血液中睾酮浓度降低有关。
