Jessop D S, Richards L J, Harbuz M S
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, UK.
Stress. 2004 Dec;7(4):261-6. doi: 10.1080/10253890400025497.
We have summarised evidence in the literature for modulatory effects of stress on inflammatory autoimmune disease. We find that overall there is strong evidence for such an interrelationship. Apparent discrepancies between groups and studies are probably due to differences in experimental design, whether longitudinal or retrospective. Other important variables are the specific effects of different types of stress and the intensity and timing of the stressor relative to onset of inflammation. We conclude that there is much of benefit to be learned from scientific study of stress, such as harnessing and rationalising of stressful experiences through self-expression in patients, or the identification of novel anti-inflammatory compounds activated by stress.
我们总结了文献中关于应激对炎症性自身免疫病调节作用的证据。我们发现总体上有强有力的证据支持这种相互关系。不同组和研究之间明显的差异可能是由于实验设计的不同，无论是纵向研究还是回顾性研究。其他重要变量包括不同类型应激的特定效应以及应激源相对于炎症发作的强度和时间。我们得出结论，对应激的科学研究有很多益处，比如通过患者自我表达来利用和合理化应激经历，或者识别由应激激活的新型抗炎化合物。
