Kaminagayoshi Tatsuhiko, Nakao Kumiko, Yashiki Shinji, Sonoda Shunro, Ohba Norio, Sakamoto Taiji
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Ocul Immunol Inflamm. 2005 Apr-Jun;13(2-3):199-204. doi: 10.1080/09273940590928670.
To investigate the immunogenetic background of human T-cell lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) that presents immune-mediated reactive changes in the uvea.
HLA class I and class II genes were studied in 51 patients with HAU, 192 asymptomatic HTLV-1 carriers, and 266 HTLV-1-seronegative controls using a high-resolution method of HLA DNA typing. The HLA alleles of HAU were compared with those of HTLV-1 carriers and healthy controls.
We identified 62 distinct alleles of HLA-A, HLA-Cw, and HLA-B and 49 distinct alleles of HLA-DRB1 and HLA-DQB1 in patients with HAU, asymptomatic HTLV-1 carriers, and healthy controls. The relative frequencies of these HLA alleles did not differ among the three groups.
The results suggest that HLA class I and class II genes do not contribute to susceptibility to HAU.
研究人类1型嗜T细胞病毒（HTLV-1）相关性葡萄膜炎（HAU）的免疫遗传背景，该疾病在葡萄膜中呈现免疫介导的反应性变化。
采用高分辨率HLA DNA分型方法，对51例HAU患者、192例无症状HTLV-1携带者和266例HTLV-1血清阴性对照者的HLA I类和II类基因进行研究。将HAU患者的HLA等位基因与HTLV-1携带者和健康对照者的进行比较。
我们在HAU患者、无症状HTLV-1携带者和健康对照者中鉴定出62个不同的HLA-A、HLA-Cw和HLA-B等位基因以及49个不同的HLA-DRB1和HLA-DQB1等位基因。这些HLA等位基因的相对频率在三组之间没有差异。
结果表明，HLA I类和II类基因对HAU的易感性没有影响。
