Preliminary clinical experience with androgen administration for pre- and postmenopausal women with hypoactive sexual desire.

The present study examined effects of testosterone on hypoactive sexual desire in pre- and postmenopausal women (treated) compared with an age-matched reference group (reference). Treated participants received 100 mg of testosterone cypionate in oil injected intramuscularly (i.m.) monthly for 3 months. We measured salivary testosterone and scores on the Sexual Desire Inventory pretreatment and posttreatment. Treated and reference participants' baseline testosterone was equivalent, however, treated participants exhibited higher testosterone levels than did reference participants posttreatment. As expected, treated participants exhibited lower baseline sexual desire than did reference participants and showed a significant increase in sexual desire posttreatment. This research suggests that testosterone may effectively alleviate hypoactive sexual desire, even in women with normal testosterone levels.