胎儿循环中的氧化应激并不取决于分娩方式。

Oxidative stress in the fetal circulation does not depend on mode of delivery.

作者信息

Fogel Itay, Pinchuk Ilya, Kupferminc Michael J, Lichtenberg Dov, Fainaru Ofer

机构信息

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, and Department of Obstetrics and Gynecology, Lis Maternity Hospital, Israel.

出版信息

Am J Obstet Gynecol. 2005 Jul;193(1):241-6. doi: 10.1016/j.ajog.2004.10.637.

DOI:10.1016/j.ajog.2004.10.637

PMID:16021086

Abstract

OBJECTIVE

We tested whether neonates are subject to oxidative stress by comparing the susceptibility of umbilical blood lipids with copper-induced peroxidation.

STUDY DESIGN

Umbilical arterial and venous blood samples were drawn from 32 pregnant women who delivered by elective cesarean section (CS) and from 32 pregnant women who delivered by spontaneous vaginal delivery (SVD) in a tertiary care center. Oxidative stress was evaluated by spectrophotometric monitoring of copper-induced peroxidation of serum samples.

RESULTS

The lag preceding lipid peroxidation in umbilical arterial blood was shorter than the lag in umbilical venous blood, irrespective of mode of delivery (14.0+/-1.8 vs 50.6+/-8.25 min, P=.0004 in SVD group; 17.7+/-1.6 vs 39.2+/-7.6 min, P=.006 in CS group).

CONCLUSION

Umbilical arterial lipids are more susceptible to peroxidation than umbilical venous lipids, indicating high oxidative stress in the fetal circulation irrespective of mode of delivery.

摘要