Vassallo José, Paes Roberto Pinto, Soares Fernando Augusto, Menezes Yara, Aldred Vera, Ribeiro Karina de Cássia Braga, Alves Antonio Correa
Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
Sao Paulo Med J. 2005 May 2;123(3):134-6. doi: 10.1590/s1516-31802005000300009. Epub 2005 Jul 8.
It is currently asserted that, in industrialized countries, nodular sclerosis is the most frequent type of Hodgkin's lymphoma, in contrast to developing countries, where mixed cellularity and lymphocyte depletion are more frequently seen. The objective was to review histological data from cases of Hodgkin's lymphoma from São Paulo and Campinas cities.
Cross-sectional histopathological analysis, in four university hospitals and one cancer care center.
1,025 cases diagnosed as Hodgkin's lymphoma between 1990 and 2000 were collected from five institutions; 631 of them (61.5%) had been immunophenotyped using antibodies to CD20, CD3, CD15 and CD30. The relative frequencies of histological types (as informed by the contributing authors, who are hematopathologists in their institutions) were determined according to age and gender.
The Hodgkin's lymphoma types were distributed as follows: lymphocyte predominance 4.8%, nodular sclerosis 69.2%, mixed cellularity 21.1% and lymphocyte depletion 4.6%.
The controversy regarding the frequencies of Hodgkin's lymphoma types within the Brazilian setting seems to be due to the small number of cases in previous studies. The present data show a picture close to the situation in the industrialized countries.
目前认为，在工业化国家，结节硬化型是霍奇金淋巴瘤最常见的类型，而在发展中国家，混合细胞型和淋巴细胞消减型更为常见。目的是回顾圣保罗市和坎皮纳斯市霍奇金淋巴瘤病例的组织学数据。
在四家大学医院和一家癌症护理中心进行横断面组织病理学分析。
从五家机构收集了1990年至2000年间诊断为霍奇金淋巴瘤的1025例病例；其中631例（61.5%）使用抗CD20、CD3、CD15和CD30抗体进行了免疫表型分析。根据年龄和性别确定组织学类型的相对频率（由各机构的血液病理学家提供）。
霍奇金淋巴瘤各类型分布如下：淋巴细胞为主型4.8%，结节硬化型69.2%，混合细胞型21.1%，淋巴细胞消减型4.6%。
巴西国内关于霍奇金淋巴瘤各类型频率的争议似乎是由于以往研究中的病例数量较少。目前的数据显示出与工业化国家情况相近的情形。
