抗逆转录病毒药物药理学
Pharmacology of antiretroviral drugs.
作者信息
Hoetelmans R M
机构信息
Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.
出版信息
Antivir Ther. 1999;4 Suppl 3:29-41.
PMID:16021869
Abstract
In this paper, an overview of the pharmacokinetics of currently available antiretroviral drugs is provided. Included in this article are the agents zidovudine, stavudine, zalcitabine, lamivudine, didanosine, abacavir, nevirapine, delavirdine, efavirenz, saquinavir, indinavir, ritonavir and nelfinavir. Key pharmacokinetic parameters, drug penetration in body compartments and drug interactions are discussed for each agent.
摘要
本文提供了目前可用抗逆转录病毒药物的药代动力学概述。本文涵盖的药物有齐多夫定、司他夫定、扎西他滨、拉米夫定、去羟肌苷、阿巴卡韦、奈韦拉平、地拉韦啶、依非韦伦、沙奎那韦、茚地那韦、利托那韦和奈非那韦。针对每种药物讨论了关键药代动力学参数、药物在身体各部位的渗透情况以及药物相互作用。
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