Swidzińska Ewa, Ossolińska Maria, Naumnik Wojciech, Izycki Tomasz, Kucejko Wojciech, Chyczewska Elzbieta
Kliniki Chorób Płuc i Gruźlicy AM w Białymstoku.
Pneumonol Alergol Pol. 2004;72(9-10):389-94.
Angiogenesis plays an important role in the pathogenesis of lung cancer. This process is caused by the imbalance between stimulating and inhibiting agents. VEGF is a key stimulator having a biologic effect via two different receptors of tyrosine kinase: VEGF-R1 and VEGF-R2. A soluble form of sVEGF-R1 is a negative regulator of VEGF activity. The serum concentrations of VEGF, sVEGF-R1 were assayed in 24 patients with NSCLC and 13 patients with SCLC and 10 healthy volunteers by means of ELISA method. The serum concentrations of VEGF were significantly higher in patients than in controls (p=0.016). The concentration of sVEGF-R1 was not significantly different in patients and controls. No statistically significant differences were established between the concentrations of VEGF, and sVEGF-R1 with regard to such clinical features, as: performance staging, clinical staging (stage III vs. stage IV) and histological pattern (NSCLC vs. SCLC). The significantly higher VEGF concentrations were reported in patients with the tumor of more than 7.5 cm in the diameter (p=0.027). Analyzing the influence of the response to treatment on the concentrations of parameters examined, a significant increase in VEGF concentration was demonstrated in the case of disease progression (p=0.034). The concentrations of sVEGF-R1 did not change after treatment. No correlation was found between parameters examined.
血管生成在肺癌发病机制中起重要作用。这一过程由刺激因子和抑制因子之间的失衡所致。血管内皮生长因子（VEGF）是一种关键的刺激因子，通过两种不同的酪氨酸激酶受体：VEGF-R1和VEGF-R2发挥生物学效应。可溶性形式的sVEGF-R1是VEGF活性的负调节因子。采用酶联免疫吸附测定（ELISA）法检测了24例非小细胞肺癌（NSCLC）患者、13例小细胞肺癌（SCLC）患者及10名健康志愿者血清中VEGF、sVEGF-R1的浓度。患者血清VEGF浓度显著高于对照组（p = 0.016）。患者与对照组sVEGF-R1浓度无显著差异。在VEGF和sVEGF-R1浓度方面，就以下临床特征而言未发现统计学显著差异：体能状态分期、临床分期（Ⅲ期与Ⅳ期）和组织学类型（NSCLC与SCLC）。直径大于7.5 cm的肿瘤患者VEGF浓度显著更高（p = 0.027）。分析治疗反应对所检测参数浓度影响时发现，疾病进展时VEGF浓度显著升高（p = 0.034）。治疗后sVEGF-R1浓度未改变。所检测参数之间未发现相关性。
