Hoehne Francesca M, Taylor Edward
Surgery Department, Kern Medical Center, 1830 Flower Street, Bakersfield, CA 93305, USA.
Am Surg. 2005 Feb;71(2):159-63.
Breast cancer mortality has changed dramatically with improvements in screening techniques. Mammography is essential for early detection; however, its contribution to the survival benefit in young women is questionable. We report our experience in breast biopsies at a county teaching hospital with a traditionally younger patient population. Institutional review board approval was obtained prior to data collection. A total of 550 breast biopsies were conducted between 1995 and 2000. Data regarding age, method of breast biopsy, and pathology was reviewed. One hundred twenty of 550 patients (21.8%) had breast carcinoma detected on breast biopsies with the predominant histologic subtype being invasive ductal carcinoma. The mean age of patients with carcinoma was 52.8 years, whereas that of patients with benign breast disease was 43.6 years (P < 0.05). Forty-three per cent of all breast cancers occurred in women under the age of 50 years. During the study period, there was neither an increase in the number of breast biopsies performed per year nor a decrease in the average age of women with breast cancer. However, observing a significant percentage of breast cancer patients under 50 years old, our data suggest the importance of strict adherence to current screening recommendations including self-breast examination and yearly mammography.
随着筛查技术的改进，乳腺癌死亡率发生了显著变化。乳腺钼靶摄影对于早期发现至关重要；然而，其对年轻女性生存获益的贡献值得怀疑。我们报告了在一家县级教学医院对传统上较为年轻的患者群体进行乳腺活检的经验。在收集数据之前获得了机构审查委员会的批准。1995年至2000年间共进行了550例乳腺活检。对年龄、乳腺活检方法和病理数据进行了回顾。550例患者中有120例（21.8%）在乳腺活检时检测出患有乳腺癌，主要组织学亚型为浸润性导管癌。患癌患者的平均年龄为52.8岁，而患有良性乳腺疾病的患者平均年龄为43.6岁（P<0.05）。所有乳腺癌中有43%发生在50岁以下的女性中。在研究期间，每年进行的乳腺活检数量既没有增加，乳腺癌女性的平均年龄也没有下降。然而，鉴于观察到相当比例的乳腺癌患者年龄在50岁以下，我们的数据表明严格遵守包括自我乳房检查和每年乳腺钼靶摄影在内的当前筛查建议的重要性。
