Pease James E, Horuk Richard
Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK.
Expert Opin Investig Drugs. 2005 Jul;14(7):785-96. doi: 10.1517/13543784.14.7.785.
Chemokines (chemotactic cytokines) are a family of low-molecular-weight proteins that direct the cellular migration of leukocytes by binding to and activating the G protein-coupled receptors displayed on the leukocyte cell surface. The inadvertent or excessive generation of chemokines has been associated with the inflammatory component of several disease processes, and consequently, considerable efforts have been made to characterise chemokine/chemokine receptor interactions with the ultimate aim of therapeutic intervention. This review focuses on the biology of CC chemokine receptor 1, which together with its ligands is thought to recruit leukocytes during the progression of rheumatoid arthritis, multiple sclerosis and organ transplant rejection. The developments made in antagonising this receptor and efficacies of these compounds in the clinical setting are also highlighted.
趋化因子（趋化性细胞因子）是一类低分子量蛋白质，通过与白细胞表面展示的G蛋白偶联受体结合并激活这些受体，来引导白细胞的细胞迁移。趋化因子的意外产生或过度产生与多种疾病过程的炎症成分相关，因此，人们付出了巨大努力来表征趋化因子/趋化因子受体相互作用，其最终目标是进行治疗干预。本综述着重探讨CC趋化因子受体1的生物学特性，该受体及其配体被认为在类风湿性关节炎、多发性硬化症和器官移植排斥反应的进展过程中募集白细胞。本文还强调了在拮抗该受体方面取得的进展以及这些化合物在临床环境中的疗效。
