Posther K E, Wells S A
Department of Surgery, Duke University School of Medicine, American College of Surgeons Oncology Group, Durham, NC, USA.
Eur J Surg Oncol. 2005 Aug;31(6):695-701. doi: 10.1016/j.ejso.2005.02.018. Epub 2005 Apr 26.
The American College of Surgeons Oncology Group (ACOSOG) was established in 1997; it is funded by the National Cancer Institute (NCI) and American College of Surgeons (ACS) for the purpose of conducting multicenter phases II and III clinical trials in the field of surgical oncology. After eight years, ACOSOG has successfully completed seven trials and has five studies currently open to accrual for patients with brain, breast, gastrointestinal, head and neck, and lung cancers. The history of randomized controlled trials in surgery and the structure and function of ACOSOG are discussed. ACOSOG is establishing an extensive specimen bank for current and future correlative science studies, providing unique educational opportunities for surgeons in clinical research, and pursuing collaborative relationships in order to conduct trials with private industries. Also, ACOSOG has expanded its membership to include international sites, which contribute to the success of ACOSOG studies and enhance the portfolio of future protocols. The participation of general surgeons and surgical oncologists in clinical trials is essential to the improvement of treatment options for cancer patients.
美国外科医师学会肿瘤学组（ACOSOG）成立于1997年；它由美国国立癌症研究所（NCI）和美国外科医师学会（ACS）资助，目的是在外科肿瘤学领域开展多中心II期和III期临床试验。八年后，ACOSOG已成功完成七项试验，目前有五项研究正在招募脑癌、乳腺癌、胃肠道癌、头颈癌和肺癌患者。本文讨论了外科随机对照试验的历史以及ACOSOG的结构和功能。ACOSOG正在建立一个广泛的标本库，用于当前和未来的相关科学研究，为外科医生提供临床研究方面独特的教育机会，并寻求合作关系以便与私营企业开展试验。此外，ACOSOG已扩大其成员范围，纳入了国际站点，这有助于ACOSOG研究的成功，并丰富了未来试验方案的组合。普通外科医生和外科肿瘤学家参与临床试验对于改善癌症患者的治疗选择至关重要。
