凋亡中的线粒体分裂

Mitochondrial fission in apoptosis.

作者信息

Youle Richard J, Karbowski Mariusz

机构信息

Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63. doi: 10.1038/nrm1697.

DOI:10.1038/nrm1697

PMID:16025099

Abstract

Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that the mitochondrial fission machinery actively participates in the process of programmed cell death.

摘要

线粒体在细胞内持续融合和分裂，形成一个动态网络。细胞凋亡过程中的一个步骤是线粒体碎片化，最近的证据表明，线粒体分裂机制积极参与程序性细胞死亡过程。