Merz Sandra, Hammermeister Miriam, Altmann Katrin, Dürr Mark, Westermann Benedikt
Institut für Zellbiologie, Universität Bayreuth, D-95440 Bayreuth, Germany.
Biol Chem. 2007 Sep;388(9):917-26. doi: 10.1515/BC.2007.110.
Mitochondria are amazingly dynamic organelles. They continuously move along cytoskeletal tracks and frequently fuse and divide. These processes are important for maintenance of mitochondrial functions, for inheritance of the organelles upon cell division, for cellular differentiation and for apoptosis. As the machinery of mitochondrial behavior has been highly conserved during evolution, it can be studied in simple model organisms, such as yeast. During the past decade, several key components of mitochondrial dynamics have been identified and functionally characterized in Saccharomyces cerevisiae. These include the mitochondrial fusion and fission machineries and proteins required for maintenance of tubular shape and mitochondrial motility. Taken together, these findings reveal a comprehensive picture that shows the cellular processes and molecular components required for mitochondrial inheritance and morphogenesis in a simple eukaryotic cell.
线粒体是极其动态的细胞器。它们沿着细胞骨架轨道持续移动，并频繁地融合和分裂。这些过程对于维持线粒体功能、细胞分裂时细胞器的遗传、细胞分化以及细胞凋亡都很重要。由于线粒体行为机制在进化过程中高度保守，因此可以在酵母等简单模式生物中进行研究。在过去十年中，酿酒酵母中线粒体动态变化的几个关键成分已被鉴定并进行了功能表征。这些成分包括线粒体融合和分裂机制以及维持管状形态和线粒体运动所需的蛋白质。综上所述，这些发现揭示了一幅全面的图景，展示了简单真核细胞中线粒体遗传和形态发生所需的细胞过程和分子成分。
