Toll样受体8（TLR8）和Toll样受体7（TLR7）参与宿主对人细小病毒1型的免疫反应。
TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1.
作者信息
Triantafilou Kathy, Vakakis Emmanouil, Orthopoulos George, Ahmed Mohamed Abd Elrahman, Schumann Christian, Lepper Philipp M, Triantafilou Martha
机构信息
University of Sussex, Infection and Immunity group, School of Life Sciences, Brighton, UK.
出版信息
Eur J Immunol. 2005 Aug;35(8):2416-23. doi: 10.1002/eji.200526149.
Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro-inflammatory molecules by the host.
Toll样受体（TLR）在调节针对微生物病原体的免疫反应中起关键作用。细菌、病毒或真菌成分与TLR结合会导致炎性细胞因子的产生和释放。在本研究中，我们发现主要是TLR8以及TLR7作为人细小病毒1（一种单链RNA（ssRNA）病毒）的宿主传感器。此外，我们发现这些TLR在内体区室中检测到病毒ssRNA基因组，其激活信号传导，导致宿主合成促炎分子。
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