Mackarel A Jill, Plant Barry J, FitzGerald Muiris X, O'Connor Clare M, Martin Lorraine, Elborn J Stuart, Gallagher Charles G
Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Exp Lung Res. 2005 May;31(4):377-90. doi: 10.1080/019021490927060.
Excessive neutrophil recruitment to the lung underlies inflammatory-mediated lung damage in cystic fibrosis (CF). Neutrophils can migrate to the lung using either a CD18-dependent or CD18-independent mechanism. To determine if one of these migratory pathways is preferentially utilized by neutrophils migrating to the CF airways, this study examined the CD18 dependency of neutrophil transendothelial migration stimulated by the soluble fraction of CF sputum (SOL). Results demonstrate the preferential use of the CD18-independent migratory mechanism by both control and CF neutrophils and suggest that selective blocking of the CD18-independent migration pathway may offer a means of decreasing neutrophil influx to the CF airways.
中性粒细胞过度募集至肺部是囊性纤维化（CF）中炎症介导的肺损伤的基础。中性粒细胞可通过CD18依赖性或CD18非依赖性机制迁移至肺部。为了确定迁移至CF气道的中性粒细胞是否优先利用这些迁移途径之一，本研究检测了CF痰液可溶性部分（SOL）刺激的中性粒细胞跨内皮迁移对CD18的依赖性。结果表明，对照和CF中性粒细胞均优先使用CD18非依赖性迁移机制，并提示选择性阻断CD18非依赖性迁移途径可能为减少中性粒细胞流入CF气道提供一种方法。
