Yamada Toshiyuki
Department of Clinical Pathology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421.
Rinsho Byori. 2005 Jun;53(6):558-61.
C-reactive protein (CRP) and serum amyloid A (SAA) are sensitive acute phase reactants. Both, but predominantly CRP in Japan, have long been used for monitoring inflammatory diseases. During the recent wave of measuring both at low concentration ranges and utilizing these values to clarity certain disorders involving low grade inflammation, we need to remain aware of factors other than apparent inflammation that can influence these values. These include age, obesity, hyperlipidemia, glucose intolerance, silent atherosclerosis, and therapeutic use of hypolipidemic agents or glucocorticoid. Genetic polymorphism may also be an influence; especially an allelic variant of SAA1 has been proposed to have a positive effect on SAA concentrations. Understanding this, these values should not be evaluated at a single sampling point but used kinetically in the individual.
C反应蛋白（CRP）和血清淀粉样蛋白A（SAA）是敏感的急性期反应物。长期以来，二者，尤其是在日本主要是CRP，一直被用于监测炎症性疾病。在最近一波在低浓度范围内同时测量二者并利用这些值来明确某些涉及低度炎症的疾病的过程中，我们需要留意除明显炎症之外可能影响这些值的其他因素。这些因素包括年龄、肥胖、高脂血症、葡萄糖不耐受、无症状动脉粥样硬化以及使用降血脂药物或糖皮质激素进行治疗。基因多态性也可能产生影响；特别是有人提出SAA1的一个等位基因变体对SAA浓度有正向作用。了解到这一点，这些值不应在单个采样点进行评估，而应在个体中动态使用。
