Yamada T, Sakurai A
Department of Clinical Pathology, Jichi Medical School, Tochigi.
Rinsho Byori. 1997 Jul;45(7):696-8.
Serum amyloid A (SAA) is a sensitive acute phase reactant; its serum level increases up to 1,000 fold of the healthy level (less than 10 micrograms/ml). Recently, the diagnostic usefulness of this protein in comparison with C-reactive protein (CRP) has been discussed in disorders or situations which show slight elevation of these protein levels, especially, in subjects receiving glucocorticoid therapies. To clarify physiological changes of this protein, day to day variations in SAA values of 23 healthy individuals were investigated and it was shown that majority (91%) had dynamic ranges of less than 3.0 micrograms/ml. Effect of dexamethasone administration on SAA and CRP values was studied in 10 subjects who received a dexamethasone suppression test. Changes in SAA values were within the physiological variation, and discrepancy in the changes between SAA and CRP as previously described in subjects with glucocorticoid therapies was not shown.
血清淀粉样蛋白A（SAA）是一种敏感的急性期反应物；其血清水平可升高至健康水平（低于10微克/毫升）的1000倍。最近，在这些蛋白质水平略有升高的疾病或情况下，特别是在接受糖皮质激素治疗的受试者中，已经讨论了这种蛋白质与C反应蛋白（CRP）相比的诊断用途。为了阐明这种蛋白质的生理变化，研究了23名健康个体SAA值的每日变化，结果表明大多数（91%）个体的动态范围小于3.0微克/毫升。在10名接受地塞米松抑制试验的受试者中研究了地塞米松给药对SAA和CRP值的影响。SAA值的变化在生理变化范围内，未显示出如先前在糖皮质激素治疗受试者中所描述的SAA和CRP变化之间的差异。
