一项关于包含甲基丙烯酸、明胶和四（羟甲基）氯化鏻（MAGAT）的常氧聚合物凝胶剂量计的研究。
A study of a normoxic polymer gel dosimeter comprising methacrylic acid, gelatin and tetrakis (hydroxymethyl) phosphonium chloride (MAGAT).
作者信息
Hurley C, Venning A, Baldock C
机构信息
School of Physical and Chemical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, Qld 4001, Australia.
出版信息
Appl Radiat Isot. 2005 Oct;63(4):443-56. doi: 10.1016/j.apradiso.2005.03.014.
In this study, the response to ionsing radiation of the normoxic polymer gel dosimeter comprising tetrakis (hydroxymethyl) phosphonium chloride (THPC) with methacrylic acid (MAA) and gelatin, named MAGAT, has been investigated. Using magnetic resonance imaging (MRI), the R2-dose response or change in R2 (DeltaR2) is evaluated for different concentrations of the component chemicals: THPC, MAA, gelatin and hydroquinone (HQ). The formulation for which the MAGAT polymer gel dosimeter had a maximum response was determined, and the spatial and temporal stability for this formulation analyzed. It was found that the formulation that provided the greatest change in R2 was 10 mM THPC, 0-0.05 mM HQ, 6-7% gelatin and 4-6% MAA (evaluated one day post-irradiation). MAGAT polymer gel dosimeters comprising 10mM THPC, 0.05 mM HQ, 6-9% MAA and 4-6% gelatin have shown potential for use in radiation therapy dosimetry.
在本研究中，对一种由氯化四羟甲基鏻（THPC）与甲基丙烯酸（MAA）和明胶组成的常氧聚合物凝胶剂量计（名为MAGAT）对电离辐射的响应进行了研究。使用磁共振成像（MRI），针对不同浓度的成分化学品（THPC、MAA、明胶和对苯二酚（HQ））评估了R2剂量响应或R2的变化（ΔR2）。确定了MAGAT聚合物凝胶剂量计具有最大响应的配方，并分析了该配方的空间和时间稳定性。结果发现，在辐照后一天评估时，使R2变化最大的配方为10 mM THPC、0 - 0.05 mM HQ、6 - 7%明胶和4 - 6% MAA。包含10 mM THPC、0.05 mM HQ、6 - 9% MAA和4 - 6%明胶的MAGAT聚合物凝胶剂量计已显示出在放射治疗剂量测定中的应用潜力。
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