[Clinical analysis of 120 cases of malignancies with nosocomial infections].

OBJECTIVE

To explore the clinical features and treatment of nosocomial infections in patients with malignancies in the period of agranulocytosis following chemotherapy.

METHODS

The clinical features of hospital-acquired infections were reviewed and analyzed in 120 patients with malignancies in state of agranulocytosis after chemotherapy. The infection-related factors, classification of the pathogens and therapeutic effect were also analyzed.

RESULTS

The hospital-acquired infections involved mostly patients with acute leukemia and lung cancer (70/120), occurring at the site of the respiratory tract (78.89%), oral mucosa, gastrointestinal tract, skin and abdominal cavity, etc. The pathogens responsible for the infection are mainly bacteria, with increased incidence of mycotic infections. The pathogenic bacteria causing the infections were predominately G-bacterium, which were sensitive to meropenem and imipenem/cilastatin.

CONCLUSION

Patients with malignancies are at high risk of hospital-acquired infection. Good basic nursing care, intestinal tract disinfection, application of granulocyte-stimulating factors, adequate use of antibiotics and constant vigilance of mycotic infection are the key measures to prevent and treat these nosocomial infections.