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白细胞介素2(IL2)在急性髓系白血病治疗中的应用:临床与生物学研究结果

Interleukin 2 (IL2) in the management of acute myeloid leukemia: clinical and biological findings.

作者信息

Foa R, Meloni G, Guarini A, Vignetti M, Marchis D, Tosti S, Tos A G, Vischia F, Mandelli F, Gavosto F

机构信息

Dipartimento di Scienze Biomediche e Oncologia Umana, University of Torino, Italy.

出版信息

Leukemia. 1992;6 Suppl 3:115S-116S.

PMID:1602806
Abstract

In this paper we review some of the preclinical findings which have led us to believe that immunotherapy with interleukin 2 (IL2)/lymphokine activated killer (LAK) cells may be a feasible approach in the management of acute myeloid leukemia. The main clinical and biological results so far obtained with IL2 treatment, and the currently ongoing protocols and strategies are discussed.

摘要

在本文中,我们回顾了一些临床前研究结果,这些结果使我们相信,白细胞介素2(IL2)/淋巴因子激活的杀伤细胞(LAK)免疫疗法可能是治疗急性髓系白血病的一种可行方法。本文还讨论了迄今为止用IL2治疗所获得的主要临床和生物学结果,以及目前正在进行的方案和策略。

相似文献

1
Interleukin 2 (IL2) in the management of acute myeloid leukemia: clinical and biological findings.白细胞介素2(IL2)在急性髓系白血病治疗中的应用:临床与生物学研究结果
Leukemia. 1992;6 Suppl 3:115S-116S.
2
Peripheral blood and bone marrow immunophenotypic and functional modifications induced in acute leukemia patients treated with interleukin 2: evidence of in vivo lymphokine activated killer cell generation.白细胞介素-2治疗急性白血病患者后外周血及骨髓的免疫表型和功能改变:体内淋巴因子激活的杀伤细胞生成的证据
Cancer Res. 1991 Feb 1;51(3):964-8.
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Transplantation of patients with high risk acute myeloid leukemia in first remission with autologous marrow cultured in interleukin-2 followed by interleukin-2 administration.
Bone Marrow Transplant. 1994 Sep;14(3):389-96.
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Lymphokine activated killer (LAK) activity in lymphoproliferative disorders.淋巴增生性疾病中的淋巴因子激活的杀伤细胞(LAK)活性
Bone Marrow Transplant. 1989 Jan;4 Suppl 1:153-5.
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Treatment of residual disease in acute leukemia patients with recombinant interleukin 2 (IL2): clinical and biological findings.用重组白细胞介素2(IL2)治疗急性白血病患者的残留疾病:临床和生物学发现。
Bone Marrow Transplant. 1990 Jul;6 Suppl 1:98-102.
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In vitro and in vivo susceptibility of human leukemic cells to lymphokine activated killer activity.人白血病细胞在体外和体内对淋巴因子激活的杀伤活性的敏感性。
Leukemia. 1988 Jan;2(1):50-4.
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Immunotherapy with donor leukocyte infusions for patients with relapsed acute myeloid leukemia following partially mismatched related donor bone marrow transplantation.
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In vitro susceptibility of acute leukemia cells to the cytotoxic activity of allogeneic and autologous lymphokine activated killer (LAK) effectors: correlation with the rate and duration of complete remission and with survival.
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Role of postinduction immunotherapy in acute myeloid leukemia.诱导后免疫疗法在急性髓系白血病中的作用。
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Ineffectiveness of adoptive chemoimmunotherapy with lymphokine-activated killer cells, interleukin-2, and cyclophosphamide on palpable intradermal murine bladder cancer.采用淋巴因子激活的杀伤细胞、白细胞介素-2和环磷酰胺进行的过继性化学免疫疗法对可触及的皮内小鼠膀胱癌无效。
J Biol Response Mod. 1988 Feb;7(1):43-53.

引用本文的文献

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Soluble interleukin-2 receptor α activation in a Children's Oncology Group randomized trial of interleukin-2 therapy for pediatric acute myeloid leukemia.可溶性白细胞介素 2 受体 α 在儿童肿瘤组随机试验中对儿童急性髓细胞白血病的白细胞介素 2 治疗的激活作用。
Pediatr Blood Cancer. 2011 Sep;57(3):398-405. doi: 10.1002/pbc.22966. Epub 2011 Jun 16.
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Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer.白细胞介素-2。其药理学特性及在癌症患者中的治疗应用综述。
Drugs. 1993 Sep;46(3):446-514. doi: 10.2165/00003495-199346030-00009.