Rosato A, Bronte V, Pollis F, Mandruzzato S, Zambon A, Zanovello P, Collavo D
Institute of Oncology, University of Padova, Italy.
Leukemia. 1992;6 Suppl 3:166S-167S.
The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interfering with CTL generation and localization in the tumor mass.
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