Schmits R, Kündig T M, Baker D M, Shumaker G, Simard J J, Duncan G, Wakeham A, Shahinian A, van der Heiden A, Bachmann M F, Ohashi P S, Mak T W, Hickstein D D
Amgen Institute, Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada.
J Exp Med. 1996 Apr 1;183(4):1415-26. doi: 10.1084/jem.183.4.1415.
The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed normal ex vivo CTL function. However, LFA-1-deficient mice did not reject immunogenic tumors grafted into footpads and did not demonstrate priming response against tumor-specific antigen. Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal.
白细胞整合素LFA-1（CD11a/CD18）在淋巴细胞再循环和同型相互作用中起重要作用。缺乏CD11a的小鼠的白细胞在体外同型聚集、混合淋巴细胞反应中的增殖以及对有丝分裂原的反应方面存在缺陷。突变小鼠对全身性淋巴细胞脉络丛脑膜炎病毒（LCMV）和水泡性口炎病毒（VSV）感染产生正常的细胞毒性T细胞（CTL）反应，并显示出正常的体外CTL功能。然而，缺乏LFA-1的小鼠不能排斥移植到足垫的免疫原性肿瘤，也未表现出针对肿瘤特异性抗原的启动反应。因此，CD11a缺陷导致外周免疫反应诱导的选择性缺陷，而对全身感染的反应正常。
