Tong Ming, Ai Jun-kui, Yuan Yi-ming, Yin Yi, Zhou Li-qun, Xin Dian-qi, Li Ming, Na Yan-qun
Department of Urinary Surgery, Peking University First Hospital, Beijing 100034, China.
Zhonghua Yi Xue Za Zhi. 2005 May 25;85(19):1319-21.
To investigate the association between A49T polymorphism of SRD5A2 gene and risk of prostate cancer.
PCR was used to examine the A49T polymorphisms of SRD5A2 gene in the tissues of prostate cancer resected from 112 patients (CaP group) and the specimens of benign prostate hyperplasia (BPH group) resected from 89 patients. The association of A49T polymorphism with age of onset, FPSA, TPSA, F/T, T stage, and Gleason score were analyzed.
There was no significant difference in A49T polymorphism between the CaP and BPH groups (P > 0.05). The average age of CaP patients was significantly higher than that of the BPH patients (P < 0.05). In the CaP patients, the Gleason score was significantly higher, and the age of onset was significantly lower in the AT + TT genotype than in the AA genotype (both P < 0.05) 2. The age of onset of the AA + AT group was significantly lower than that of the AA group (P < 0.05).
AA + AT genotype may be of worse prognosis, however, without significant difference. Rank scoring may reflect the relation between Gleason score and A49T genotype and estimate the prognosis better than two-level discrete evaluation.
探讨SRD5A2基因A49T多态性与前列腺癌风险之间的关联。
采用聚合酶链反应（PCR）检测112例前列腺癌患者切除组织（前列腺癌组）和89例良性前列腺增生患者切除标本（良性前列腺增生组）中SRD5A2基因的A49T多态性。分析A49T多态性与发病年龄、游离前列腺特异性抗原（FPSA）、总前列腺特异性抗原（TPSA）、F/T比值、T分期及Gleason评分的相关性。
前列腺癌组与良性前列腺增生组之间A49T多态性无显著差异（P>0.05）。前列腺癌患者的平均年龄显著高于良性前列腺增生患者（P<0.05）。在前列腺癌患者中，AT+TT基因型的Gleason评分显著高于AA基因型，发病年龄显著低于AA基因型（均P<0.05）。AA+AT组的发病年龄显著低于AA组（P<0.05）。
AA+AT基因型可能预后较差，但无显著差异。等级评分可能反映Gleason评分与A49T基因型之间的关系，比两级离散评估能更好地估计预后。
