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移植后肝静脉闭塞病:发病机制、诊断与治疗

Post-transplant hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment.

作者信息

Ho Vincent, Momtaz Parisa, Didas Colleen, Wadleigh Martha, Richardson Paul

机构信息

Department of Adult Oncology, Division of Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Rev Clin Exp Hematol. 2004 Jun 1;8(1):E3.

Abstract

Hepatic veno-occlusive disease (VOD) is one of the most important complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality when severe. This review addresses the pathogenesis and clinical features of VOD and outlines the role on endothelial cell injury and risk factors. The current status of research for both treatment and prevention are discussed.

摘要

肝静脉闭塞病(VOD)是造血干细胞移植(SCT)后最重要的并发症之一,严重时与极高的死亡率相关。本文综述了VOD的发病机制和临床特征,概述了内皮细胞损伤的作用及危险因素,并讨论了治疗和预防的研究现状。

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