Kaplan D
Chemotherapy. 1979;25(6):346-51. doi: 10.1159/000237862.
Minimum bactericidal concentrations of salicylate, nicotinaldehyde singly, and in combination with nicotinic acid, or nicotinamide were determined for Staphylococcus aureus 79 and 80, and Escherichia coli 95, at inocula of 10(7)--10(2). The bactericidal dose of salicylate was affected markedly by the inoculum size. The bactericidal dose of nicotinic acid, or nicotinamide was affected only slightly by the size of the inoculum. Escherichia coli 95 was least affected by the inoculum size. Nicotinaldehyde is a far more bactericidal agent than is nicotinic acid, or nicotinamide; its bactericidal dose was approximately a tenth that of nicotinic acid, or nicotinamide. S. aureus 79 and 80 were affected synergistically by the combinations of nicotinic acid, or nicotinamide with salicylate. Nicotinaldehyde reduced the effectiveness of nicotinic acid, at all inoculum sizes, of S. aureus 79, while the reduction of effectiveness of nicotinamide was only found with inocula of 10(7)--10(5). At low inocula, 10(4)--10(2), an additive effect was demonstrated. S. aureus 80 was antagonistically affected, at all inoculum sizes, by the combination of nicotinaldehyde with nicotinamide, while with nicotinic acid a slight synergy was noted. In contrast, Escherichia coli 95 was antagonistically affected, at all inoculum sizes, by combinations of nicotinic acid, nicotinamide with salicylate, or nicotinaldehyde.
测定了水杨酸盐、烟醛单独以及与烟酸或烟酰胺联合使用时，针对金黄色葡萄球菌79和80以及大肠杆菌95在接种量为10(7)--10(2)时的最低杀菌浓度。水杨酸盐的杀菌剂量受接种量大小的影响显著。烟酸或烟酰胺的杀菌剂量仅受接种量大小的轻微影响。大肠杆菌95受接种量大小的影响最小。烟醛作为一种杀菌剂，其杀菌能力远比烟酸或烟酰胺强；其杀菌剂量约为烟酸或烟酰胺的十分之一。金黄色葡萄球菌79和80受到烟酸或烟酰胺与水杨酸盐组合的协同影响。在所有接种量下，烟醛都会降低金黄色葡萄球菌79中烟酸的有效性，而仅在接种量为10(7)--10(5)时才发现烟酰胺有效性的降低。在低接种量（10(4)--10(2)）时，呈现出相加效应。在所有接种量下，金黄色葡萄球菌80受到烟醛与烟酰胺组合的拮抗影响，而与烟酸组合时则观察到轻微的协同作用。相比之下，在所有接种量下，大肠杆菌95受到烟酸、烟酰胺与水杨酸盐或烟醛组合的拮抗影响。
