Mittelman A, Puccio C, Chun H, Ahmed T
Department of Medicine, New York Medical College, Valhalla 10595.
Mt Sinai J Med. 1992 May;59(3):234-7.
This study has shown that a mouse antiidiotypic mAb bearing a mirror image of HMW-MAA can break tolerance to a well-defined self HMW-MAA and can induce humoral anti HMW-MAA immunity in patients with melanoma. Furthermore, the induction of an immune response to a well-defined melanoma-associated antigen has been shown to be associated with a favorable clinical response. If this association reflects a cause-effect relationship between the two parameters, the anti HMW-MAA immunity induced by mouse antiidiotypic mAb MK2-23 may effect immune destruction of melanoma cells and may interfere with the metastatic potential of those cells because of the suggested role of HMW-MAA in this phenomenon.
本研究表明，携带高分子量黑色素瘤相关抗原（HMW-MAA）镜像的小鼠抗独特型单克隆抗体（mAb）可打破对明确的自身HMW-MAA的耐受性，并可在黑色素瘤患者中诱导体液抗HMW-MAA免疫。此外，已证明对明确的黑色素瘤相关抗原的免疫反应诱导与良好的临床反应相关。如果这种关联反映了这两个参数之间的因果关系，那么小鼠抗独特型mAb MK2-23诱导的抗HMW-MAA免疫可能会影响黑色素瘤细胞的免疫破坏，并可能干扰这些细胞的转移潜能，因为HMW-MAA在这一现象中具有所提示的作用。
