Rúzsás C, Józsa R, Mess B
Endocrinol Exp. 1979 Mar;13(1):9-18.
Thyroid function was investigated in adult male rats following the use experimental procedures which inhibit the activity of serotoninergic neuron system. Pharmacological blockade of the biosynthesis of sertonin by repeated administration of para-chlorophenylalanine (pCPA), or interruption (by Halász knife) of the serotoninergic pathways of the brain stem which terminate on hypothalamic nuclei equally resulted in an augmentation of the following parameters of hypothalamo-hypophysial-thyroid activity: T/S ratio, pituitary and blood TSH levels and blood thyroxine concentration as well as TRH content of the hypothalamus. The results suggest that the central nervous serotoninergic neuron system plays an inhibitory role in the regulation of TSH secretion, presumably acting upon the hypothalamus, thereby inhibiting hypothalamic TRH secretion.
在成年雄性大鼠中，采用抑制血清素能神经元系统活性的实验程序后，对其甲状腺功能进行了研究。通过反复给予对氯苯丙氨酸（pCPA）对血清素生物合成进行药理阻断，或用哈拉斯刀中断终止于下丘脑核的脑干血清素能通路，同样导致下丘脑 - 垂体 - 甲状腺活动的以下参数增加：T/S比值、垂体和血液中的促甲状腺激素（TSH）水平、血液甲状腺素浓度以及下丘脑的促甲状腺激素释放激素（TRH）含量。结果表明，中枢神经血清素能神经元系统在促甲状腺激素分泌的调节中起抑制作用，可能作用于下丘脑，从而抑制下丘脑促甲状腺激素释放激素的分泌。
